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65 Does the paradox that either GIPR agonist or antagonist exhibits benefits in combination with GLP-1R agonist correlates with the likely reduction of internalization, following the decrement of -arrestin recruitment or the acceleration of the dissociation rate (K off ) between the ligand and receptor, owing to competition between used agonists and antagonists in endogenous GIP
International scheduling Australia's Therapeutic Goods Administration (interim decision, April 2024) and New Zealand's Medsafe (Medicines Classification Committee, June 2025) have moved to schedule BPC-157 as a prescription-only medicine, despite its unavailability through legitimate prescription
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