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By principal component analysis of the RNA sequencing data, the differences in gene expression profiles between patients was generally much greater than the differences in gene expression induced by BAT (Supplemental Figure 7A)

Key Research Focus Areas Peptide-metal interaction studies Molecular signaling pathway research Biochemical coordination chemistry analysis Peptide stability and degradation research In-vitro experimental peptide models All information associated with GHK-Cu is derived from experimental and preclinical research contexts only

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Such bidirectional interaction between hyperandrogenism and insulin resistance/hyperinsulinemia likely plays a key role in the pathogenesis of PCOS 12,13,14 , since elevated testosterone promotes obesity and insulin resistance/hyperinsulinemia by altering body composition and insulin signaling in skeletal muscle and adipose tissue, while hyperinsulinemia contributes to increase androgen levels via ovarian-dependent mechanisms 5