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This is the single biggest practical concern with the stack

In a Phase 2 obesity trial of retatrutide published in the New England Journal of Medicine in 2023, nausea, diarrhea, vomiting and constipation were cited as the most common adverse events, with higher doses associated with more severe problems

Retatrutide's results are also not as fast-acting as methods like the protein-sparing modified fast, a medically monitored diet in which people take in around 800 calories per day, Yerevanian says

Lifestyle & Nutrition Coaching We offer guidance on diet, exercise, and habitsbecause studies show combining GLP1s with lifestyle support boosts long-term results