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One reason for the failures could be that 50% of AD patients exhibit -synuclein pathology, while 30% show TDP43 pathology (Robinson et al., Iron dyshomeostasis appears to be a common theme, unifying neurodegenerative diseases including AD, Lewy Body disease, and frontotemporal dementia (FTD)

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Tirzepatide has been studied in the literature in relation to body-weight outcomes, appetite regulation, glycaemic control, insulin signalling and incretin biology

Cycling Strategy: 6 weeks on, 2 weeks off maintains receptor sensitivity