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Upon receptor binding, IGF1R undergoes autophosphorylation, initiating downstream signaling pathways, including: Phosphoinositide 3-kinase (PI3K)/Akt pathway Mitogen-activated protein kinase (MAPK) pathway These pathways are associated with intracellular signal transduction processes, including regulation of gene expression, protein translation, and cellular signaling dynamics at the molecular level
We test for the four things it can't see
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Infected and treated PBMCs were maintained at 37C, with 5% CO 2 until they were terminated at 8- or 15-days post-infection
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