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A p53-phosphoinositide signalosome regulates nuclear AKT activation
Proteins were detected using horseradish peroxidase (HRP)-conjugated IgG secondary antibody (#7074, Cell Signaling and 62-6520, Thermo Fisher Scientific) and SignalFire ECL Reagent (Cell Signaling)
This is particularly relevant for oral contraceptives and medicines with a narrow therapeutic index
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