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201 DDR-targeted agents promote immunogenic cell death by inducing micronuclei formation, enhancing TMB, and activating innate immune pathways such as cGASSTING, thereby augmenting ICB efficacy
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Foundational Discovery Selective Senolytic Elimination in Aged Mice (Cell, 2017 Baar et al.) FOXO4-DRI Restores Fitness, Fur Density, Renal and Liver Function in Aged Mice The foundational study introducing FOXO4-DRI as a senolytic peptide was published in Cell by Baar and colleagues in 2017
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