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318,319 GIPR has been detected in adipose tissue and genetic ablation of GIPR in mice has clearly shown the importance that GIP has on fat uptake: GIPR-deficient mice did not develop weight gain and adiposity to the same degree as control mice even though they were on the same high-fat diets

The present study replicates the previously observed dementia risk reduction with SGLT2 inhibitor versus DPP4 inhibitor initiation in people with diabetes [12,13,14,15], but limited studies with adequate events have explored the association between continuous use of SGLT2 inhibitors and dementia aetiologies [13]