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[7] Starting mid-2026, Medicare beneficiaries with obesity + heart disease risk may pay ~$50/month copays

This is thought mainly due to folic acid from dietary supplements [40]

Drug-induced malabsorption: Long-term medications like metformin or proton-pump inhibitors can reduce B12 absorption

(Again, the oral dose is significantly higher than the injectable, because a lot of it is degraded in the GI tract.) Orforglipron seems to be slightly less effective