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The glucose-dependent nature of semaglutides insulin secretion generally results in a lower intrinsic risk of hypoglycemia compared to insulin or sulfonylureas, but the combination effect must be carefully managed
Side effects are generally mild and temporary (nausea, flushing, injection site tenderness)
doi: 10.1056/NEJMoa2307563
If a pregnant patient has a documented deficiency of one or more B vitamins or a condition like hyperemesis that prevents oral intake, the benefits of correcting the deficiency (preventing serious maternal and fetal complications) outweigh any minimal risk from the injection
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