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Activating the Wnt/Beta-Catenin Pathway The Wnt/beta-catenin signaling pathway is central to hair follicle regeneration
We treated the MOLP-8 myeloma cell line with increasing concentrations of the ERK5-CHAMP RNK06138 for 24 h and observed a dose-dependent decrease in ERK5 protein levels with a Dmax (maximum degradation) of 74% and DC 50 (half-maximal degradation concentration) of 111.7 nM
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The number reflects the binding proteins the assay measures, the platform that produced it, what the patient has been exposed to, and the clinical picture around it
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