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Glutathione, a tripeptide composed of cysteine, glutamic acid, and glycine, is a powerful antioxidant naturally produced by the liver
This observation means that xCT blockage induces the accumulation of glutamate that is converted into -ketoglutarate instead of being used in glutamate-cysteine exchange and consequently that is why cysteine does not enter the cell and give rise to glutathione
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