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No longterm human trials exist
According to the WHO European report, 59% of adults and children, about 27% of girls and 29% of boys, are overweight or obese (2)
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The GI side effects were not trivial either
Cardiovascular Outcomes Data Favors Semaglutide For Now The SELECT trial (published in the New England Journal of Medicine in 2023) demonstrated that semaglutide reduced major adverse cardiovascular events by 20% in patients with obesity and established cardiovascular disease
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