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A key innovation in this field is the development of designer probioticsgenetically engineered or otherwise modified commensal bacterial strains specifically tailored to withstand production stresses such as lyophilization, thermal fluctuations, and gastric acidity, or to enhance their most beneficial functions for the host (537)

Documented symptomatic hypoglycaemia (according to ADA classification) [22] was also low (three subjects [five events] in the moderate renal impairment group and two subjects [two events] in the severe renal impairment group)

Patients were followed from the index event (defined as the first co-occurrence of breast cancer and T2DM diagnoses) until either prescription of a GLP-1 receptor agonist (GLP-1RA) or censoring at their last recorded follow-up