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As research in the journal Hindawi pointed out, we can also intentionally deplete glutathione from tumor cells to make them more susceptible to chemotherapy treatments a process known as chemosensitization (13)
No tolerance development to the lipolytic effects was noted in these studies, suggesting that unlike beta-2 agonists (which rapidly desensitize their receptors), beta-3 receptor activation may not produce the same downregulation pattern
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