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Evaluation of: Glycerol production (a marker of lipolysis) 2-deoxyglucose uptake (a marker of insulin signaling) DNA synthesis (a marker of proliferation) What they found: AOD-9604 stimulated lipolysis dose-dependently from 10 M, with a plateau at 10 M Full hGH stimulated lipolysis to a similar maximum, but with different kinetics AOD-9604 did not affect glucose uptake or DNA synthesis at all, whereas hGH inhibited both (the classic lipotoxic GH effect) Fragments with different sequence (from the N-terminal part of hGH) had no lipolytic effect Why it matters: This was the first publication of AOD-9604
The answer is receptor distribution heterogeneity and microbiome composition
endogenous human peptide Sequence: glycyl-L-histidyl-L-lysine bound to a Cu 2+ ion (Gly-His-Lys:Cu) CAS Number: 89030-95-5 (GHK-Cu complex)
