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[Note: This reaction is analogous to the formation of cyclic AMP by adenylate cyclase, except that this guanylate cyclase is not membrane associated.] The resultant rise in cGMP causes activation of protein kinase G, which phosphorylates Ca 2+ channels, causing decreased entry of Ca 2+ into smooth muscle cells
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Apoptosis is stimulated by procarbazine, which induces oxidative DNA damage that cannot be repaired by the BER/NER system in Hodgkins lymphoma and brain cancers 96
