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The following considerations further strengthen the criticism toward the use of PAC as a safer alternative to NSAID: PAC has been preferred to NSAIDs and steroids for the symptomatic and domiciliary management of the early stages of COVID-19, a choice grounded of the precautionary principle (but still theoretical in this specific case) principle primum non nocere (Micallef et al., 2020a)
It is a playful name for a serious protocol, and it stuck because patients keep coming back for it
Current experimental literature does not indicate direct hepatotoxic effects under controlled research conditions
More recent advances have enabled evaluation of the molecular interactions between specific ROS and their targets in redox signalling pathways
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