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One domain senses the glutathione, and the other transports it." The protein's unique structure may explain its abilities, says Birsoy
Appropriate controls are recommended
For GHK-Cu specifically, the logic is sound even without direct evidence: cumulative copper exposure is lower with reduced frequency, and the gene expression changes initiated during loading persist during maintenance
Two distinct domains are recognized in each GST monomer: a N-terminal thioredoxin-like domain and a C-terminal alpha-helical domain
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