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doi: 10.3389/fendo.2023.1292011 141 GnencANGrafBStarkHChariA
Adsorptive-mediated transport at the BBB has also been exploited to target nanocarrier systems by using cationic lipids and cell penetrating peptides to increase binding and internalization at the brain capillary endothelium [29, 30], which has a highly negative surface charge [31]
Moreover, various agents targeting proteins involved in iron homeostasis or inducing ferroptosis are investigated preclinically or are in early clinical development
This delicate balance is an interplay between ROS production and the up-regulation of the AOX pathways CAT and GSH which opposes the apoptotic process (124)
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