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Providing support for a causal link between a negative energy state and increased Parasutterella abundance, a rat model of obesity, which showed similar Parasutterella relative abundances in animals maintained on HFD and those maintained on normal chow but exhibited a treatment-induced increase in Parasutterella relative abundance, displayed a negative correlation between Parasutterella and body weight 82

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Skipping this step can lead to issues if B12 levels arent where they need to be, resulting in potential side effects or a deficiency relapse

Selective NNMT inhibitor (5-amino-1MQ) reduces adiposity in DIO mice