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Severe nausea requiring treatment discontinuation was rare in monotherapy trials, with only about 1% of participants in the REDEFINE 1 trial stopping treatment because of adverse events overall
Studies have shown that increased intake of CoQ-10 significantly increased the percentage of sperm with forward movement and average sperm velocity (Balercia 2004)
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The skin changes are not dramatic at 8 weeks but become clinically visible at the 12 to 16-week mark in most patients
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