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The evaluating clinician determines whether a compounded option is appropriate based on individual health factors
For instance, most empirical evidence is derived from animal models, such as mice and boars, whereas studies using human clinical samples remain limited
Potency and PK anchors: Lau 2015 (cAMP EC50 6.2 pmol/L), Boianelli 2024 (free fraction 0.36%), FDA 2021 (weight-change EC50 54.6 nmol/L)
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