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A sterile lyophilized (freeze-dried) powder keeps the 600mg of active stable in the sealed vial until it is reconstituted into solution immediately before use, helping ensure it is administered in its active form
The concentrations in other tissues were lower than the average concentration in the plasma and are presented in the descending order as follows: intestinal tract, lung, gonad, skin, skeletal muscle, cardiac muscle, whole blood, brain, and body fat
For instance, chemotherapy drugs such as fluorouracil (5-FU), methotrexate, etoposide, and melphalan carry a higher risk of mucositis than other chemotherapy agents, but the development of mucositis is not limited to these agents alone
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