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It acts directly on neighboring -cells to inhibit the secretion of glucagon and can also indirectly influence -cells by inhibiting the secretion of other hormones
Interestingly, Napolitano et al
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TB-500 (and the full T4 parent protein) has been characterized within the actin-sequestration mechanism, forming a 1:1 complex with monomeric ATP-G-actin via the LKKTET contact residues 17-22 of the parent protein [3] [4]
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