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Insulin, GLP-1 agonists such as semaglutide, growth-hormone secretagogues, and most peptide drugs work as receptor ligands or hormone analogues: they bind a defined cell-surface receptor and trigger a signaling cascade whose pharmacology has been mapped in exhaustive detail and tested in large registration trials

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The TRAVERSE study a large randomized trial of 5,000+ men found that testosterone therapy did not increase rates of major cardiovascular events such as heart attack or stroke compared to placebo, even in men with existing heart risk

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