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revealed that lycopene significantly decreased levels of NF-B, IL-1 and IL-6 while increasing the level of Nrf-2, implying that lycopene acts as an anti-inflammatory agent in UC by suppressing the expression of NF-B and promoting the expression of Nrf-2 (42) (Figure 2)
They are undertreated because trial populations have historically skewed male
It is also important to mention that RNA and protein levels were determined by real-time PCR and Western blotting, respectively
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