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16 A sub-study of the SURPASS-3 trial on overweight/obese patients with T2DM demonstrated that tirzepatide decreased liver fat by 8.1% over 52 weeks, along with significant reductions in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (NCT03882970), 17 indicating that tirzepatide may improve liver steatosis or inflammation
"Crosstalk between the Gut Microbiome and Colonic Motility in Chronic Constipation: Potential Mechanisms and Microbiota Modulation." Nutrients
Maloney RC, Zhang M, Liu Y, Jang H, Nussinov R (2022) The mechanism of activation of MEK1 by B-Raf and KSR1
If results hold, the drug could become a major new player in an already crowded, and highly competitive, weight loss market.
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