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These aggregates are associated with the mitochondrial tricarboxylic acid (TCA) cycle, resulting in proteotoxic stress consistent with the cuproptosis mechanism [51,54]
The fleeting nature of the GHK-Cu half life demands it
Mitochondrial complex activity The enzyme activity of CI was determined by a colourimetric analysis following the manufacturers protocol (Abcam, ab109721)
Advances in molecular biology, transcriptomics and proteomics are providing new opportunities to study peptide activity with greater precision than previously possible
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