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Unlike endogenous cannabinoids, THC also increases mitochondrial hydrogen peroxide production [39], and reactive oxygen species (ROS) production and neuronal apoptosis in mPFC [32], a brain region critically involved in neuropsychiatric pathology

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Eli Lilly says that Zepbound is a dual receptor agonist that targets both GIP and GLP-1 receptors, unlike other incretins approved for obesity management, which target only GLP-1 receptors. And Novo Nordisk says that Wegovy has the broadest GLP-1 label, including indications for reducing risk of major adverse cardiovascular events in some patients and for treatment of a certain liver condition in some adults

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