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The clinical and biological manifestations that may be encountered reflect both exaggerated therapeutic effect and impairment in metabolic pathways

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Common observations during this period include skin texture feeling slightly less plump or firm, fine lines that had completely disappeared beginning to reappear subtly, and overall skin quality remaining better than pre-treatment but noticeably less optimal than peak treatment results

The primary endpoint was the change from baseline in blood glucose level control measured using the haemoglobin A1c biomarker, at 26 weeks