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However, vitamin B12 deficiencies can also occur after drug therapy with neomycin, colchicine, PAS preparations and in the case of tapeworm infestation
Duke University
That balance is the more interesting readout of the two, because a compound that raised both synthesis and degradation would look very different in a remodeling assay from one that shifted the ratio
It also shifts melanin production from the darker eumelanin toward the lighter pheomelanin, which is why it is used for skin brightening
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