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Tirzepatide SC (Mounjaro/Zepbound): Dual GIP/GLP-1 agonism produces the greatest weight reduction among approved agents up to 2024% in non-diabetic patients (SURMOUNT-1)
Skin reactions are common (affecting 35-50% of users), including rashes, burns, and blisters
In the triple therapy cohort receiving metformin, SGLT2-i, and GLP-1RA, overbasalization declined from 62.5 to 17.5%, and 42.5% of patients were able to stop insulin entirely, reinforcing the additive benefits of combination therapy [44]
According to the available studies, DSIP is usually applied shortly before sleep onset due to its short half-life of just several minutes
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