Historically described as mere fat-solubilizing agents, these amphipathic compounds were recently recognized as key signaling molecules capable to modulate the host metabolism directly acting as ligands of intestinal GPCRs (101, 338, 339), or after being metabolized by the colonic microbiota into secondary bile acids, mostly deoxycholic and lithocholic acid(340)
Boles RG, Zaki EA, Lavenbarg T, Hejazi R, Foran P, Freeborn J, Trilokekar S, McCallum R: Are pediatric and adult-onset cyclic vomiting syndrome (CVS) biologically different conditions
During follow-up, 12 patients in the oral semaglutide (10.4%) and 11 patients in the subcutaneous semaglutide (6.2%%) group discontinued treatment due to side effects, without significant differences between the two formulations ( p = 0.27) (Supplementry Figure S2o)
This medication operates by mirroring the actions of the hormone GLP-1, fostering blood sugar regulation and satiety