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Effect of pineal peptide preparation (epithalamin) on life span and pineal and serum melatonin level in old rats

It is important to note that concentration is not the only factor determining efficacy: the galenic formulation, pH and presence of cofactors significantly influence the peptide's bioavailability

Since the liver is critical in manufacture and detoxification of hormones, this could explain a link between women suffering heavy periods and vitamin B12 deficiency and hormone imbalance