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While many patients recover after standard therapy, others continue to experience fatigue, cognitive dysfunction, pain, dizziness, or autonomic symptoms that warrant additional evaluation

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Commonly used activators include HOBt (1-hydroxybenzotriazole), HBTU (2- (4-hydroxyphenyl) -4,5-dihydro-4-methyl-6-nitroimidazolo [1,2-a] pyridine-3-one), TBTU (2- (2-pyridyldithio) benzotriazole sodium salt), etc

While physiological ovarian aging represents a gradual and predictable process, its pathological acceleration, often mediated by oxidative stress and chronic inflammation, poses a disproportionate threat to womens health, particularly when it occurs prematurely (Kobayashi et al., 2025