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FIGURE 1 In vitiligo patients, high IFN- expression has been implicated in an aggressive and permanent IS response (IFN- CXCL10 (C-X-C Motif Chemokine Ligand 10) CD8 + T cells) (Xie et al., 2016) targeting the population of epithelial cells throughout the body causing visual (Ma et al., 2021) and vascular dysfunction (Rashighi et al., 2014)
In another study, Hu et al
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Furthermore, progressive loss of NRF2 activity was seen with aging, which may be explained by studies showing that the expression of NRF2 positive regulators P62 and BRCA1 decreased with age, while NRF2 negative regulators, KEAP1 and BACH1, increased with age [113]
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