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Both medications share the same class-level gastrointestinal side effects nausea, vomiting, diarrhea, constipation, and reduced appetite
171 Additionally, small molecule drugs may have better tissue permeability, longer half-lives in the body, and lower production costs
However, because Wegovy uses higher doses of semaglutide, these side effects may be more noticeable in the first few weeks of escalation
The intensity of these adverse effects is typically dose-related, with higher dosages associated with more severe symptoms
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