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Side-effect data reported below come from per-compound Phase 2/3 trials and the closest-analog REDEFINE 1 cagrilintide+semaglutide trial
The receptor-binding sites that mediate growth hormones systemic effects (Sites 1 and 2) are located in different regions from the lipolytic domain
Gene expression levels were standardized using the z score method, and cluster analysis of DEGs in key pathways was performed using the pheatmap R package [33] based on standardized FPKM values
Most organotypic culture work has been done on rodent tissue
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