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The average 4 to 6 pound reduction over 26 to 78 weeks is statistically significant but smaller than what most patients expect from "semaglutide." For context, the STEP 1 trial of injectable semaglutide 2.4 mg weekly showed average weight loss of 33 pounds over 68 weeks in patients without diabetes
In a worst-case scenario of this study, the researchers estimated that at most, a breastfeeding baby would receive 1.26% of their mothers dose of semaglutide
It should not replace care from a rheumatologist or another specialist
Indeed, liraglutide, the first GLP- 1 RA approved for chronic weight management (in 2014) was shown in the SCALE Phase 3 trial to produce mean weight reduction from baseline to week 56, of 8.0% with liraglutide 3.0 mg versus 2.8% with placebo (last-observation-carried-forward imputationLOCF) [3]
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