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TNF- levels decreased by an average of 28% (p IL-6 levels decreased by an average of 24% (p The study found a 31% reduction in cartilage degradation markers (p The researchers used regression analysis to show that GLP-1 receptor activation has a strong negative relationship with inflammatory cytokine levels, which they measured at r = -0.68

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Amitriptyline (Elavil ), a tricyclic "antidepressant" frequently used to treat migraine, is the most widely prescribed prophylactic medication used for the treatment of CVS, with response rates varying from 52-73% in open-label and subject recall-based studies in children and adults [reviewed in 5]

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