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16 A sub-study of the SURPASS-3 trial on overweight/obese patients with T2DM demonstrated that tirzepatide decreased liver fat by 8.1% over 52 weeks, along with significant reductions in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (NCT03882970), 17 indicating that tirzepatide may improve liver steatosis or inflammation

Myostatin primarily mediates the upregulation of MAFbx gene expression through the transcription factors Smad2/3, thereby promoting protein degradation (140,141)

Older adults may need higher-quality protein with maximal digestibility and anti-inflammatory support