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Unlike sulfonylurea derivatives, metformin does not cause hypoglycemia in patients with type 2 diabetes mellitus or in healthy individuals (except in certain circumstances) and does not cause hyperinsulinemia
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The brain utilizes approximately 20% of the bodys total energy and is highly susceptible to oxidative stress owing to its high content of polyunsaturated fatty acids, which are prone to oxidation
The term incretin was later coined (in 1932 by La Barre) for this proposed intestinal insulin-stimulating substance ( [30] ) ( [29] )
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