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PubMed research supports that insulin resistance is a core factor in various health issues beyond diabetes, including fatty liver, cognitive impairment, and cardiovascular disease (Springer)
Each is described as a reason for baseline testing rather than blanket supplementation
However, other studies have indicated that POMC GLP-1R knockdown can increase HFD-induced weight gain, and ARC GLP-1R blockade by GLP-1R antagonists attenuated the anorexic effects of liraglutide [57]
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