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Once mutant and/or misfolded proteins with a loss- or gain-of-function or damaged and potentially harmful cellular structures cannot be effectively eliminated, cells undergo malignant transformation, which may progress to carcinogenesis (Edinger and Thompson, 2003)

Promega Corporation, Madison, WI, USA) digestion according to the manufacturers instructions for phosphorylation modification analysis, which using a Titansphere Phos-TiO kit (GL Sciences, Tokyo, Japan), and desalted using ZipTip C18 pipette tips (Millipore, Temecula, CA, USA)

Patients should be aware of their allergy history and inform their healthcare provider before starting treatment