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Such trials would represent the definitive test of the prevention-dominant hypothesis advanced in this review, and their results whether positive or negative would substantially clarify the role of GLP-1 receptor agonists in cognitive health

Consumers should be skeptical of any over-the-counter product marketed as a GLP-1 supplement that suggests it can act like a prescription drug, replace a GLP-1 medication or treat a disease such as obesity, says Jeff Ventura, a spokesperson for the Council for Responsible Nutrition, which represents the dietary supplement industry

For a broader look at how different supplement forms compare, this guide on supplement absorption and bioavailability from Examine is worth reading

Together, these findings necessitate further investigations to ascertain whether coordinated inhibition of NMDA receptors in GLP-1 receptor neurons modulates neuronal activity beyond canonical feeding regions, such as the mesolimbic dopaminergic reward pathway