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A reaction that depletes cellular NAD+ pools and methyl donor availability

4,7 The link between hearing loss and tinnitus has been suggested to be due to a compensatory effect: the brain compensates for decreased activation of the auditory nerve (which carries signals from the cochlea to the brain) by increasing gain or signal amplification in the auditory system of the brain, as well as decreasing auditory signal inhibition, which may result in tinnitus and possibly hypersensitivity to noise

On the other hand, with ligation of the inferior caval vein occlusion we made a recapitulation of Virchow

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