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In a phase II trial, obese participants who were administered retatrutide lost an average of 24.2 percent of their body weight over a 48-week period, Wired noted, which is more than what other drugs have achieved in nearly twice the amount of time
Chemical & Engineering News, 2026
This suggests that TSH changes observed during semaglutide treatment are likely a physiological response to weight loss rather than a direct drug effect (Reinehr, 2010, Thyroid )
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