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Although FOS is only one proxy for neuronal activity-dependent gene expression, these results suggest that acute cagrilintide treatment in rats activates Glu4.2 Calcr/Ramp3 neurons, whereas subchronic treatment additionally engages Glu8.2 NTS Calcr/Prlh neurons, with no evidence for Glu8.0 activation under any condition

Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions

Also available in 96-well spin plate formats for processing up to 96 samples

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