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For use in vitamin B12 deficiency associated with cobalt deficiency in cattle and sheep and for vitamin B12 deficiency associated with inadequate vitamin B12 intake or intestinal malbsorption in swine and horses.

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Using CRISPR-Cas9 in human and mouse cells, genome-wide, targeted loss-of-function pooled screens have been studied that has provided information about the inactivated genomic loci and strategies that modulate transcriptional activities (Shalem et al., 2015)

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